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⚠ For research use only — NOT intended for use on humans or animals. This site is informational, does not provide medical advice and does not replace the advice of a healthcare professional.

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Sleep & RecoveryNon approuvéPubMed ↗

DSIP

Delta Sleep Inducing Peptide

DSIP (Delta Sleep Inducing Peptide) is a naturally occurring 10-amino-acid peptide found in the body, studied for its role in regulating deep sleep, nervous system recovery, and neuroendocrine balance.

ProtocolReconstitution
Reconstitution
10 mg + 2 ml
5000 mcg/ml
Usual dose
200–300 mcg
beginner 100 mcg
Frequency
6×/wk
30 to 60 min before bedtime
Administration
Subcutaneous injection
Abdomen · Thigh · Upper arm

Chemical identity

Sequence
WAGGDASGE
Molecular formula
C35H48N10O15
Molecular weight
848.8 g/mol
CAS no.
62568-57-4

Purity (HPLC) measures the absence of related impurities; it is distinct from net peptide content, since salts and counter-ions (acetate, TFA) count toward the vial mass. Account for this when computing the real concentration at reconstitution.

1

Potential benefits

Sleep quality

Supports deep, restorative sleep (delta stage).

Cognitive recovery

Contributes to mental clarity and memory consolidation.

Nervous fatigue

Helps reduce mental fatigue and nervous load.

Stress management

Promotes relaxation and helps regulate stress responses.

Overall recovery

Supports physical and mental recovery.

2

Mechanism of action

  • A naturally occurring peptide in the body, involved in numerous physiological processes.
  • Promotes access to deep sleep (delta stage), the most restorative phase for the body and brain.
  • Works by supporting the body's natural mechanisms — it is not a sleeping pill.
  • Contributes to neuroendocrine homeostasis and nervous system balance.
3

Historical milestones

Research milestones, clinical trials and regulatory steps.

  1. 1963

    A sleep factor hypothesized

    In Basel, Monnier and Schoenenberger observe that cerebral venous blood from a sleeping rabbit induces delta EEG activity in an awake animal.

  2. 1977

    Isolation and sequencing

    The team isolates, characterizes and synthesizes the delta sleep-inducing peptide (DSIP), a nonapeptide of sequence Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu.

  3. 1980s

    Multifunctional studies

    Numerous studies explore effects beyond sleep, including modulation of stress, pain and neuroendocrine rhythms.

  4. 2026

    Research status

    DSIP remains an experimental peptide, with no approved drug and no clear consensus on its physiological role.

4

Evolution over time

01
A few days

Initial improvement in falling asleep and sleep depth.

02
1 to 2 weeks

Noticeable improvement in sleep quality and nervous recovery.

03
Regular use

Effects continue to improve with appropriate use.

5

Dosages & protocol

Reference dosages

Beginner
Assess tolerance
100 mcg
Common use
Most used dosage
200–300 mcg
High
Experienced users
500 mcg
Cycle
6 wk + 3 off
Timing
30 to 60 min before bedtime
Half-life
Very short plasma half-life (on the order of minutes, ~15-25 min) due to rapid enzymatic degradation; effects on sleep persist well beyond that.

Reconstitution

10 mg
vial
+
2 ml
BAC water
=
5
mg/ml
Open the calculator →

Profiles studied in the literature

  • People subject to high daily stress
  • Intense intellectual work or studies
  • Non-restorative sleep
  • Athletes in a recovery period
  • Jet lag & disrupted rhythms
  • People seeking better nervous balance

Usage tips

  • Establish a consistent sleep routine.
  • Limit screens and blue light in the evening.
  • Avoid caffeine and stimulants late in the day.
  • Favor a cool, dark, and quiet environment.
  • Combine DSIP with good lifestyle habits for optimal results.

Good to know / effects to watch

  • Studies report possible daytime drowsiness or a groggy feeling (morning "hangover") after administration.
  • Mild headaches and transient mood changes may be observed.
  • Poorly characterized neuro-hormonal effects are described, with human data remaining limited and not well consolidated.
  • Local reactions at the injection site (redness, discomfort) when the subcutaneous route is used.
  • Known hypersensitivity to the compound or any of its excipients: to be avoided. Consult a healthcare professional if in doubt.

Storage

  • Before reconstitution: store the lyophilized powder refrigerated (2-8 °C) or frozen (-20 °C), protected from light and moisture.
  • After reconstitution: keep refrigerated (2-8 °C) and use within ~28 days.
  • Do not freeze the reconstituted solution; protect it from light and do not leave it at room temperature.

Contraindications

  • Pregnancy and breastfeeding: avoid as a precaution (no human data).
  • Combination with sedatives, hypnotics, anxiolytics or alcohol: caution (risk of additive drowsiness).
  • Unstable neurological or psychiatric conditions: seek medical advice before use.
  • Known hypersensitivity to the compound or an excipient; not advised in children.
  • Experimental research compound, not approved as a medicine (FDA/EMA).
6

Possible synergistic combinations

The catalog peptides are clickable — to complete or optimize your protocol.

Epitalon

Overall support for sleep, recovery, and longevity.

View the sheet & add →
Magnésium

Promotes muscle relaxation and sleep quality.

Mélatonine

At low doses if needed, depending on individual sensitivity.

Sources & references

Links to external sources (scientific databases, trial registries, authorities). RAL Peptides is not responsible for their content.

Stacks & combinations with this peptide

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Sleep

Deep sleep & nervous recovery

Support for deep sleep (DSIP) combined with overall recovery via the nocturnal GH axis (Ipamorelin).

DSIPDelta sleep quality, nervous relaxation
IpamorelinNocturnal GH peak — recovery during sleep

Why it works

DSIP promotes access to deep sleep, the phase during which the GH peak naturally occurs and that Ipamorelin amplifies: the combination aims for more restorative sleep.

  • Take 30–60 min before bedtime.
  • Avoid stimulants late in the day so as not to counter the effect.
View the kit in the shop →

Learn more

⚠ For research use only. NOT intended for use on humans or animals. The values shown are indicative and for informational purposes ; each person reacts differently. This guide does not replace medical advice — consult a healthcare professional if in doubt.